Taking part in Alzheimer's research study

New Haven, Conn. (WTNH) - Marlene Martin and Doug Black have been together for 25 years. They know each other so well, they finish each others sentences. But Doug has to do that more often for Marlene now because his 64-year-old wife has early onset Alzheimer's disease.

"I lost my job because I couldn't do it," Martin said.

Marlene worked as an anthropologist and librarian at Yale. When she was diagnosed, the couple made a bold decision; they chose to get involved in a clinical trial and take an experimental medication instead of going on a typical course of treatment for Alzheimer's.

Marlene is taking part in the second generation vaccine study. It is a two year study that includes injections, a spinal tap, brain scans and cognitive testing.

"I think we also have seen it not only as a chance as a possible cure but a chance to help in research, and if not a cure for ourselves a cure for others in the future," Black said.

"I think it's critical in Alzheimer's disease research in general," said Dr. Chris Van Dyke, director of the Alzheimer's Disease Research Unit at Yale . "The only way we're going to make progress is if people take part in these trials."

Dr. Van Dyke said this vaccine may help clear the ameloid proteins that clog cell transmission in the brain. "I think realistically we would hope it would substantially slow progression," he said. "We don't realistically think it will turn the clock back dramatically, but may slow further deterioration."

Getting the Alzheimer's diagnosis actually helped ease tensions in Marlene and Doug's relationship. Where there used to be blame, there is now understanding.

"I think we've done pretty well," Martin said.

"We're hoping to have as much good time together as we can," Doug said.

If you would like to get involved in a clinical trial contact the Alzheimer's Disease Research Unit at Yale at http://www.alzheimers.yale.edu/ or call 203-764-8100