According to officials, four people in total will be facing charges for the crime.
Police said that during the evening hours, Enfield officers were informed that 18-year-old Brandon Sanders and 32-year-old Johnny Ford were wanted in connection to death of 23-year-old Benzel Hampton.
Authorities stated Hampton was killed in a shootout in a driveway on Tuesday.
This happened after Hampton was allegedly completing a drug deal and was attacked.
The three assailants and a driver then fled the scene and drove to a hospital where one of the alleged attackers, 36-year-old James Felix, is still undergoing treatment.
Sanders was located in a vehicle traveling northbound on Interstate 91, near exit 49. He was pulled over and taken into custody without incident.
According to police, Ford was later found at a local Motel 6, where an emergency services team was activated before he was also taken into custody.
A search warrant was then executed in the motel room, where police said they found 107 grams of crack cocaine and $17,000 in cash.
Both Sanders and Ford are being held in lieu of $1 million on fugitive from justice charges.
In Vermont, officers also arrested 32-year-old Lesine Woodson and Felix. He was shot several times during the shootout that left Hampton dead.
All suspects are expected to be charged with murder.