Route 2 Eastbound was closed between Exits 12 and 13 due to the incident.
Around 10:55 p.m., police identified the victim as 60-year-old Yvan Soucy of Colchester.
Authorities said the motorcycle was traveling eastbound when it exited the lane while navigating a curve and struck a guardrail.
Soucy was ejected from the vehicle and died from injuries sustained during the crash.
Anyone with information is asked to contact Connecticut State Police at 860-465-5400.
Free download: Access Connecticut breaking news, weather, stream newscasts live and more on-the-go with News 8 alerts directly to your phone.