According to officials, the two-vehicle collision took place on Goshen Road in between Lovers Lane and Klug Hill Road around 12:30 p.m.
Fire crews said three people were involved and two suffered “major” injuries. One person required extrication.
All three were transported by ambulance to a local hospital.
Police are encouraging motorists to find alternate routes in the area.
The cause of the crash is not known at this time.
The roadway is closed until further notice.