According to officials, the crash took place on Interstate 91 Southbound near Exit 18.
Authorities said two people were hurt during the incident. One is in stable condition, while the other is listed as serious/critical.
Related Content: Motorcycle crash on I-91 in Meriden leads to serious injuries
Police said neither person wore a helmet.
The cause of the crash is not known at this time.
The incident led to some closures, but those roads are all back open.