According to officials, on Monday, units responded to Stop & Shop located at 2335 Dixwell Avenue for a report of shoplifting.
At the scene, units learned that two people attempted to take more than $320 in merchandise and a loss prevention officer intervened.
The two then fled from the area in a vehicle and were involved in a head-on collision with another vehicle at the intersection of Putnam Avenue and Newhall Street.
Police said the duo then fled on foot.
Anyone with information is asked to contact Hamden police.