Police say that at around 1:16 p.m., officers and fire crews responded to the area of 2600 Boston Post Road for a serious crash.
One of the drivers, Elizabeth Colloty, of Guilford, was seriously injured and later died from her injuries.
The other driver involved was taken to the hospital for minor injuries. Their identity has not been released.
Boston Post Road was closed for the investigation but has since reopened.
Anyone who may have witnessed the accident is encouraged to contact Guilford Police at 203-453-8061.