Police say that at around 11 p.m., emergency crews responded to a head-on collision involving two vehicles on Flanders Road (Route 161).
Chad Ebersole, 35, of Niantic was pronounced dead on scene.
The driver of the other vehicle, 29-year-old Travis Gauvin, of Norwich, was also flown to Hartford Hospital. There is no word on his condition at this time.
The crash remains under investigation.