The determination was released Thursday, two days after the 55-year-old Spade was found dead in her Park Avenue apartment.
A housekeeper discovered her body in her bedroom. Police say she left a note that pointed to “a tragic suicide.”
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Andy Spade said in a statement Wednesday that his wife was seeing a doctor regularly and was taking medication to treat her disease.
He said she “sounded happy” the night before and her death was a complete shock.
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Andy Spade said his main concern is protecting their 13-year-old daughter’s privacy as she deals with “unimaginable grief.”